Nigel Irwin Selected Research

Hyp(3)- glucose-dependent insulinotropic polypeptide

6/2007

Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice.

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Nigel Irwin Research Topics

Disease

53	Body Weight (Weight, Body) 08/2022 - 09/2004
49	Insulin Resistance 08/2022 - 09/2004
36	Type 2 Diabetes Mellitus (MODY) 12/2021 - 12/2003
34	Obesity 08/2022 - 08/2005
5	Weight Loss (Weight Reduction) 12/2021 - 01/2015
4	Glucose Intolerance 02/2009 - 02/2006
3	Bone Resorption 10/2016 - 10/2013
2	Metabolic Diseases (Metabolic Disease) 01/2022 - 01/2021
2	Cognitive Dysfunction 11/2015 - 09/2010
2	Hypertrophy 12/2007 - 08/2005
1	Short Bowel Syndrome 01/2021
1	Body Weight Changes 01/2020
1	Weight Gain 01/2020
1	Hypoglycemia (Reactive Hypoglycemia) 04/2018
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/2015
1	Prediabetic State (Prediabetes) 11/2015
1	Inflammation (Inflammations) 11/2014
1	Insulinoma 10/2011
1	Osteoporosis 09/2010
1	Alzheimer Disease (Alzheimer's Disease) 09/2010
1	Hyperphagia (Overeating) 02/2008

Drug/Important Bio-Agent (IBA)

55	Glucose (Dextrose)FDA LinkGeneric 08/2022 - 08/2005
37	Insulin (Novolin)FDA Link 08/2022 - 08/2005
29	Peptides (Polypeptides)IBA 08/2022 - 09/2005
18	Glucagon-Like Peptide 1 (GLP 1)IBA 08/2022 - 08/2006
13	Glucagon (Glukagon)FDA Link 08/2022 - 12/2003
12	xenin 25 (xenin)IBA 01/2021 - 08/2012
10	gastric inhibitory polypeptide receptorIBA 01/2020 - 08/2005
7	Exenatide (Byetta)FDA Link 08/2022 - 02/2009
7	Blood Glucose (Blood Sugar)IBA 01/2022 - 01/2016
7	IncretinsIBA 01/2020 - 12/2003
7	Hormones (Hormone)IBA 01/2019 - 12/2003
7	Pro(3)- glucose-dependent insulinotropic polypeptideIBA 07/2012 - 09/2004
6	Streptozocin (Streptozotocin)FDA Link 01/2021 - 10/2011
6	Triglycerides (Triacylglycerol)IBA 10/2020 - 12/2007
5	Biological ProductsIBA 01/2021 - 06/2008
5	Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA 10/2013 - 09/2005
4	Cholecystokinin (Pancreozymin)IBA 01/2018 - 08/2013
4	OxyntomodulinIBA 01/2016 - 12/2013
4	EnzymesIBA 12/2015 - 02/2009
3	Pharmaceutical PreparationsIBA 01/2022 - 06/2008
3	Sitagliptin Phosphate (Januvia)FDA Link 01/2021 - 01/2019
3	Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA 01/2020 - 01/2009
3	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018 - 10/2006
3	(pGlu-Gln)-CCK-8IBA 08/2015 - 01/2013
3	monomethoxypolyethylene glycol (MPEG)IBA 08/2013 - 06/2008
2	Glucagon Receptors (Glucagon Receptor)IBA 08/2022 - 04/2014
2	Glucagon-Like Peptide-1 ReceptorIBA 12/2021 - 04/2007
2	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 01/2021 - 01/2013
2	Peptide YYIBA 01/2021 - 01/2018
2	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2020 - 11/2016
2	Liraglutide FDA Link 01/2020 - 03/2015
2	Amylases FDA Link 09/2018 - 01/2018
2	Glucagon-Like Peptide-1 Receptor AgonistsIBA 12/2015 - 02/2010
2	PalmitatesIBA 08/2012 - 02/2005
2	Metformin (Glucophage)FDA LinkGeneric 12/2010 - 10/2006
2	AdiponectinIBA 02/2009 - 06/2008
2	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 06/2008 - 02/2008
2	AM 251 (AM251)IBA 06/2008 - 02/2008
2	CannabinoidsIBA 06/2008 - 02/2008
2	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 07/2007 - 04/2006
2	Fatty Acids (Saturated Fatty Acids)IBA 02/2006 - 09/2005
1	Vasopressins (Vasopressin)IBA 01/2022
1	ApelinIBA 01/2022
1	methionine aminopeptidase 2IBA 01/2021
1	O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)IBA 01/2021
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2021
1	Pyruvic Acid (Pyruvate)IBA 01/2021
1	AmidesIBA 12/2020
1	peptide YY (1-36)IBA 01/2020
1	Ala(2)- glucose-dependent insulinotropic polypeptideIBA 01/2020
1	dapagliflozinIBA 01/2020
1	AntibodiesIBA 01/2020
1	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2020
1	LipidsIBA 01/2020
1	GastrinsIBA 09/2018
1	Peptide Hormones (Polypeptide Hormones)IBA 01/2018
1	Glutamine (L-Glutamine)FDA Link 04/2016
1	MineralsIBA 01/2016
1	Leptin ReceptorsIBA 01/2016
1	Proteins (Proteins, Gene)FDA Link 11/2014
1	8-hydroxyguanineIBA 11/2014
1	deshistidyl(1)-prolyl(4)-glutamyl(9)- glucagonIBA 10/2014
1	Peptide FragmentsIBA 05/2014
1	Olanzapine (Zyprexa)FDA Link 09/2013
1	LDL CholesterolIBA 01/2013
1	OvalbuminIBA 07/2012
1	GhrelinIBA 09/2010
1	ResistinIBA 02/2009
1	CarbenoxoloneIBA 04/2008
1	11-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)IBA 04/2008
1	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 04/2008
1	Dipeptidyl-Peptidase IV InhibitorsIBA 07/2007
1	Hyp(3)-palmitoylLys(16)- glucose-dependent insulinotropic polypeptideIBA 06/2007

Therapy/Procedure

14	Therapeutics 01/2022 - 02/2005
4	Injections 02/2009 - 09/2005
3	Intraperitoneal Injections 12/2007 - 02/2006
1	Bariatric Surgery 12/2021
1	Transplantation 10/2011
1	Glycemic Control 01/2009